Lipoprotein-X fails to inhibit hydroxymethylglutaryl coenzyme A reductase in HepG2 cells.

@article{Edwards1993LipoproteinXFT,
  title={Lipoprotein-X fails to inhibit hydroxymethylglutaryl coenzyme A reductase in HepG2 cells.},
  author={Catherine M. C. Edwards and M P Otal and Peter W. Stacpoole},
  journal={Metabolism: clinical and experimental},
  year={1993},
  volume={42 7},
  pages={807-13}
}
Abnormalities of lipid composition and metabolism are frequently observed in patients with cholestatic liver disease. Both elevated low-density lipoprotein (LDL) levels and the appearance of lipoprotein-X (LP-X) in plasma underlie the high incidence of hypercholesterolemia in this population. We tested the hypothesis that the hypercholesterolemia of cholestasis may reflect a failure of normal feedback regulation of hepatic cholesterogenesis by determining the influence of LP-X on the rate… CONTINUE READING
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