Lipoprotein Lipase as a Prognostic Marker in Chronic Lymphocytic Leukemia
@article{Mtrai2016LipoproteinLA, title={Lipoprotein Lipase as a Prognostic Marker in Chronic Lymphocytic Leukemia}, author={Zolt{\'a}n M{\'a}trai and Hajnalka Andrikovics and Anik{\'o} Szilv{\'a}si and Andras Bors and Andr{\'a}s Kozma and Emma {\'A}d{\'a}m and Gabriella Halm and {\'E}va Kar{\'a}szi and Attila Tordai and Tam{\'a}s Masszi}, journal={Pathology \& Oncology Research}, year={2016}, volume={23}, pages={165-171} }
The marked clinical heterogeneity of CLL makes early prognosis assessment important. Lipoprotein lipase (LPL) has been shown to confer adverse prognosis in CLL, recent data indicating it might also contribute to CLL cell survival and metabolism. We determined LPL mRNA expression in unselected peripheral blood of 84 CLL patients by RT PCR. Results were correlated with other prognostic markers and outcome. 30/84 (40 %) of cases were LPL positive based on the cutoff established by ROC analysis. In…
8 Citations
Analysis of LPL gene expression in patients with chronic lymphocytic leukemia.
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LPL expression was found to be closely correlated with IGHV gene mutational status and overall survival, proving LPL as prognostic marker in CLL.
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Despite LPL being found to be a reliable molecular marker for CLL prognosis, its functional role and the molecular mechanisms regulating its expression are still matter of debate and some insights are provided into where currently unexplored questions may lead to.
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CD150 expression was decreased in CLL patients compared with the control group, with great heterogeneity between CLL Patients, and can be a useful tool in identifying B-CLL patient’s risk.
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The data support a model in which LPL is bound to a heparin-like heparan sulfate proteoglycan motif on the BC cell surface and acts in concert with the VLDL receptor to rapidly internalize intact lipoproteins via receptor-mediated endocytosis.
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