Lipoprotein FtsB in Streptococcus pyogenes Binds Ferrichrome in Two Steps with Residues Tyr137 and Trp204 as Critical Ligands

@inproceedings{Li2013LipoproteinFI,
  title={Lipoprotein FtsB in Streptococcus pyogenes Binds Ferrichrome in Two Steps with Residues Tyr137 and Trp204 as Critical Ligands},
  author={Hui Li and Nan Li and Qian Ya Xu and Chuanle Xiao and Hongcui Wang and Z. Sheng Guo and Jing Zhang and Xuesong Sun and Q He},
  booktitle={PloS one},
  year={2013}
}
Lipoprotein FtsB is a component of the FtsABCD transporter that is responsible for ferrichrome binding and uptake in the Gram-positive pathogen Streptococcus pyogenes. In the present study, FtsB was cloned and purified from the bacteria and its Fch binding characteristics were investigated in detail by using various biophysical and biochemical methods. Based on the crystal structures of homogeneous proteins, FtsB was simulated to have bi-lobal structure forming a deep cleft with four residues… CONTINUE READING
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