Lipoprotein(a) in the cerebrospinal fluid of neurological patients with blood-cerebrospinal fluid barrier dysfunction.

@article{Pepe2006LipoproteinaIT,
  title={Lipoprotein(a) in the cerebrospinal fluid of neurological patients with blood-cerebrospinal fluid barrier dysfunction.},
  author={G. Pepe and Guglielmina Chimienti and Grazia Maria Liuzzi and Biagia Leila Lamanuzzi and Marina Nardulli and Francesco Lolli and Eduardo {\'A}ngles-Cano and Sabrina Mat{\`a}},
  journal={Clinical chemistry},
  year={2006},
  volume={52 11},
  pages={
          2043-8
        }
}
BACKGROUND Lipoprotein(a) [Lp(a)] is a recognized pathogenic particle in human plasma, but its presence in the cerebrospinal fluid and its possible role in the central nervous system have not been documented. We tested the hypothesis that apolipoprotein(a) [apo(a)], free or as a component of the Lp(a) particle, can cross the blood-cerebrospinal fluid barrier and be found in the cerebrospinal fluid of patients affected by neurologic pathologies. METHODS We studied paired cerebrospinal fluid… CONTINUE READING