Lipoprotein(a) impairs generation of plasmin by fibrin-bound tissue-type plasminogen activator. In vitro studies in a plasma milieu.

@article{Rouy1991LipoproteinaIG,
  title={Lipoprotein(a) impairs generation of plasmin by fibrin-bound tissue-type plasminogen activator. In vitro studies in a plasma milieu.},
  author={D Rouy and P Grailhe and Fabienne Nigon and John B. Chapman and Eduardo {\'A}ngles-Cano},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1991},
  volume={11 3},
  pages={629-38}
}
Apoprotein(a), (apo[a]), the specific antigen of lipoprotein(a) (Lp[a]), consists of structural domains (a serine protease unit, kringles 4 and 5) with marked homology to those of the corresponding domains in plasminogen. In this study, we have investigated the impact of this unique structural mimicry on the binding and activation of plasminogen by fibrin-bound tissue-type plasminogen activator at the plasma-fibrin interface. We found that the total amount of plasmin generated on the surface of… CONTINUE READING

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Angl6s-Cano E: The mechanism of activation of plasminogen at the fibrin surface by t-PA in a plasma milieu in vitro: Role of alpha-2 antiplasmin

  • D Rouy
  • Biochem J 1990;271:51-57
  • 1990
1 Excerpt

The competitive binding of lipoprotein ( a ) and plasminogen to plasmin degraded fibrin

  • E Angl6s-Cano, V Fleury, D Rouy, J Chapman
  • Circulation
  • 1990

The mechanism of activation of plasminogen at the fibrin surface by tPA in a plasma milieu in vitro : Role of alpha - 2 antiplasmin

  • D Rouy, E Angl6s-Cano
  • Biochem J
  • 1990

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