Lipopolysaccharides stimulate adrenomedullin synthesis in intestinal epithelial cells: Release kinetics and secretion polarity

@article{Kishikawa2009LipopolysaccharidesSA,
  title={Lipopolysaccharides stimulate adrenomedullin synthesis in intestinal epithelial cells: Release kinetics and secretion polarity},
  author={Hiroshi Kishikawa and Jiro Nishida and Hitoshi Ichikawa and Shogo Kaida and Toshifumi Hibi},
  journal={Peptides},
  year={2009},
  volume={30},
  pages={906-912}
}
Adrenomedullin (AM), a potent vasodilator peptide initially isolated from a human pheochromocytoma, functions as an antimicrobial peptide in host defense. In this study, we investigated changes in AM levels in intestinal epithelial cells and the mechanism of its secretion and cellular polarity after exposure to lipopolysaccharides (LPS). When a rat small intestinal cell line (IEC-18 cells) was exposed to LPS, enzyme-linked immunosorbent assay revealed a dose-dependent increase in AM together… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

) 906 – 912 912 with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection

T Tsuruda, J Kato, +3 authors Y Koiwaya
  • 2009