Lipopolysaccharides and trophic factors regulate the LPS receptor complex in nodose and trigeminal neurons.

@article{Kunda2014LipopolysaccharidesAT,
  title={Lipopolysaccharides and trophic factors regulate the LPS receptor complex in nodose and trigeminal neurons.},
  author={Patricia Elena Kunda and Juan Carlos Cavicchia and Cristian Acosta},
  journal={Neuroscience},
  year={2014},
  volume={280},
  pages={60-72}
}
Binding of bacterial lipopolysaccharides (LPS) to toll-like receptor 4 (TLR4) triggers an innate immunoresponse associated with pain and inflammation. The expression, and to a greater extent the regulation of TLR4 and its auxiliary proteins (myeloid differentiation protein 1 (MD1), myeloid differentiation protein 2 (MD2) and cluster of differentiation 14 (CD14)), are both poorly understood in trigeminal and nodose neurons. We used a combination of Western blotting, semi-quantitative polymerase… CONTINUE READING

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