Lipopolysaccharides Reduce Adipogenesis in 3T3-L1 Adipocytes Through Activation of NF-κB Pathway and Downregulation of AMPK Expression

@article{Wang2013LipopolysaccharidesRA,
  title={Lipopolysaccharides Reduce Adipogenesis in 3T3-L1 Adipocytes Through Activation of NF-κB Pathway and Downregulation of AMPK Expression},
  author={Lifeng Wang and Linlin Li and Xinjian Ran and Mei Long and Minfang Zhang and Yicun Tao and Xin Luo and Ye Wang and Yi Jiao and Xinmin Mao and Jun Ren},
  journal={Cardiovascular Toxicology},
  year={2013},
  volume={13},
  pages={338-346}
}
Lipopolysaccharides (LPS) from the outer membrane of Gram-negative bacteria serve as endotoxin to exert potent immune responses. However, the effect of LPS on adipogenesis has not been elucidated. The present study was designed to examine the effect of LPS on adipogenesis in 3T3-L1 preadipocytes and possible mechanism(s) of action involved. Our results revealed that LPS challenge significantly suppressed adipogenesis in 3T3-L1 preadipocytes mainly through downregulated expression of the late… CONTINUE READING
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