Lipopolysaccharide stimulation of dendritic cells induces interleukin-10 producing allergen-specific T cells in vitro but fails to prevent allergic airway disease.

@article{Ahrens2009LipopolysaccharideSO,
  title={Lipopolysaccharide stimulation of dendritic cells induces interleukin-10 producing allergen-specific T cells in vitro but fails to prevent allergic airway disease.},
  author={Birgit Ahrens and Tobias Freund and Ro-Dug Rha and A. M. Dittrich and David Quarcoo and Andreas Hutloff and Eckard H. Hamelmann},
  journal={Experimental lung research},
  year={2009},
  volume={35 4},
  pages={307-23}
}
Dendritic cells (DCs) play an important role in directing naive T cells towards a Th1/Th2 or regulatory T cells (Treg) cell phenotype. In this context, interleukin (IL)-10 has been shown to exhibit immune regulatory capacities. The aim of this study was to delineate the influence of high-IL-10-producing DCs on DC-T-cell interactions in inhibiting allergen-induced airway inflammation and hyperreactivity in a murine model of allergic airway disease. Bone marrow-derived dendritic cells (BMDCs… CONTINUE READING