Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop.

@article{Brown2013LipopolysaccharideSP,
  title={Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop.},
  author={Gregory T Brown and Padmini Narayanan and Wei Li and Roy L Silverstein and Thomas M McIntyre},
  journal={Journal of immunology},
  year={2013},
  volume={191 10},
  pages={5196-203}
}
LPS activates platelets through TLR4, aiding productive sepsis, with stimulated splicing and translation of stored heteronuclear pro-IL-1β RNA. Although the IL-1R type 1 (IL-1R1) receptor for IL-1 shares downstream components with the TLR4 receptor, platelets are not known to express IL-1R1, nor are they known to respond to this cytokine. We show by flow cytometry and Western blotting that platelets express IL-1R1, and that IL-1β and IL-1α stimulate heteronuclear I-1β splicing and translation… CONTINUE READING

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