Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate

@article{Werry2011LipopolysaccharidestimulatedIR,
  title={Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate},
  author={Eryn L. Werry and Guo Jun Liu and Michael D Lovelace and Romesh Nagarajah and Max R. Bennett},
  journal={Neuroscience},
  year={2011},
  volume={175},
  pages={93-103}
}
Interleukin-10 (IL-10) is a cytokine with important endogenous and therapeutic anti-inflammatory effects. Given this, it is of interest to investigate factors that modulate IL-10 levels in the central nervous system. IL-10 is released after lipopolysaccharide (LPS) stimulation of microglia. Microglia also express functional glutamate receptors and in inflammatory conditions are exposed to increased levels of glutamate. The aim of this research, then, is to investigate whether glutamate can… CONTINUE READING

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