Lipopolysaccharide promoted opening of the porin channel.

  title={Lipopolysaccharide promoted opening of the porin channel.},
  author={Jun Ishii and Taiji Nakae},
  journal={FEBS letters},
  volume={320 3},
We show here that the imipenem (a carbapenem, beta-lactam antibiotic)-permeable porin channels (protein D2 or OprD2) of Pseudomonas aeruginosa were closed mostly in the lipopolysaccharide (LPS)-free membrane and were openable by adding LPS to the membrane as assayed by ion conductivity measurements using planar lipid bilayers. Open and closed states of the OprD2 channels exhibited conductivities of about 400 and 30 pS, respectively, in 1 M NaCl. The OprD2 channel in the LPS-containing membrane… CONTINUE READING

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