Lipopolysaccharide pretreatment modulates the disease course in experimental autoimmune encephalomyelitis.

@article{Buenafe2007LipopolysaccharidePM,
  title={Lipopolysaccharide pretreatment modulates the disease course in experimental autoimmune encephalomyelitis.},
  author={Abigail C. Buenafe and Dennis N. Bourdette},
  journal={Journal of neuroimmunology},
  year={2007},
  volume={182 1-2},
  pages={32-40}
}
Treatment with the bacterial product lipopolysaccharide (LPS) prior to the induction of experimental autoimmune encephalomyelitis (EAE) consistently led to a delayed onset of disease but not to a reduction in disease severity. T cell proliferation was reduced in LPS-treated mice, due at least in part to a loss in antigen presenting cell function. T cell and macrophage infiltration into the CNS was delayed and TNFalpha production was diminished in LPS pre-treated mice, consistent with the delay… CONTINUE READING
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