Lipopolysaccharide preconditioning induces robust protection against brain injury resulting from deep hypothermic circulatory arrest.

@article{Hickey2007LipopolysaccharidePI,
  title={Lipopolysaccharide preconditioning induces robust protection against brain injury resulting from deep hypothermic circulatory arrest.},
  author={Edward J. Hickey and Xiaomang You and Vassil Kaimaktchiev and Mary P. Stenzel-Poore and Ross M. Ungerleider},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2007},
  volume={133 6},
  pages={1588-96}
}
OBJECTIVE Delayed preconditioning genetically reprograms the response to ischemic injury. Subclinical bacterial lipopolysaccharide acts through preconditioning, powerfully protecting against experimental stroke. We investigated the potential for lipopolysaccharide to protect against brain injury related to cardiopulmonary bypass. METHODS Neonatal piglets were blindly and randomly preconditioned with lipopolysaccharide (n = 6) or saline (n = 6). Three days later, they experienced 2 hours of… CONTINUE READING