Lipopolysaccharide or Whole Bacteria Block the Conversion of Inflammatory Monocytes into Dendritic Cells In Vivo

@article{Rotta2003LipopolysaccharideOW,
  title={Lipopolysaccharide or Whole Bacteria Block the Conversion of Inflammatory Monocytes into Dendritic Cells In Vivo},
  author={Gianluca Rotta and Emmerson W. Edwards and Sabina Sangaletti and Clare Bennett and Simona Ronzoni and Mario P Colombo and Ralph Marvin Steinman and Gwendalyn J Randolph and Maria Rescigno},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={198},
  pages={1253 - 1263}
}
Monocytes can develop into dendritic cells (DCs) that migrate to lymph nodes (LNs) and present antigens to T cells. However, we find that this differentiation is blocked when monocytes accumulate subcutaneously in response to bacteria or lipopolysaccharide (LPS). The inhibition of DC differentiation is mediated by the bacteria and in conjunction with inflammatory cells recruited at the site of injection. Inhibition of migratory DC development was reversed in Toll-like receptor (TLR)4-mutated… CONTINUE READING
48 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…