Lipopolysaccharide modulation of normal enterocyte turnover by toll-like receptors is mediated by endogenously produced tumour necrosis factor alpha.

@article{Ruemmele2002LipopolysaccharideMO,
  title={Lipopolysaccharide modulation of normal enterocyte turnover by toll-like receptors is mediated by endogenously produced tumour necrosis factor alpha.},
  author={Frank M. Ruemmele and J F Beaulieu and Serge Dionne and {\'E}mile L{\'e}vy and Ernest G Seidman and Nadine Cerf-Bensussan and Michael J. Lentze},
  journal={Gut},
  year={2002},
  volume={51 6},
  pages={842-8}
}
BACKGROUND Circulating levels of endotoxin (or lipopolysaccharide (LPS)) and anti-endotoxin antibodies are increased in patients with inflammatory bowel disease, supporting the hypothesis of a role for endogenous bacterial products in the pathogenesis of these disorders. AIM The aim of this study was to analyse the direct effects of LPS on intestinal epithelial cell turnover. METHODS AND RESULTS LPS significantly inhibited growth of the human non-transformed immature crypt cell line (HIEC… CONTINUE READING

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