Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression.

  title={Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression.},
  author={Hsien-Yeh Hsu and Meng-Hsuan Wen},
  journal={The Journal of biological chemistry},
  volume={277 25},
Lipopolysaccharide (LPS) stimulates macrophages to release inflammatory cytokines, interleukin-1 beta (IL-1), and tumor necrosis factor (TNF). LPS-induced TNF suppresses scavenger receptor functions in macrophages (van Lenten, B. J., and Fogelman, A. M. (1992) J. Immunol. 148, 112-116), which is regulated by TNF-mediated protein kinases (Hsu, H. Y., and Twu, Y. C. (2000) J. Biol. Chem. 275, 41035-41048). To examine the molecular mechanism for LPS induction of IL-1 in macrophages, we… CONTINUE READING
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Biochem. Bio LPS-mediated ROS and Signals in Regulation of Pro-IL-1/IL-1 22138 by gest on A uust 31

R. Matsuno, Y. Aramaki, H. Arima, S. Tsuchiya
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