Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells.

@article{Duryee2004LipopolysaccharideIA,
  title={Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells.},
  author={Michael J Duryee and Lynell W. Klassen and Thomas L. Freeman and Monte S Willis and Dean J. Tuma and Geoffrey M Thiele},
  journal={Alcoholism, clinical and experimental research},
  year={2004},
  volume={28 12},
  pages={1931-8}
}
BACKGROUND The nonparenchymal cells of the liver have been suggested to play a significant role in the inflammatory processes observed in the development and/or progression of alcoholic liver disease. Our laboratories have shown that malondialdehyde-acetaldehyde (MAA)-modified proteins can induce immune responses, cytokine/chemokine secretion, and antigen processing and presentation by liver sinusoidal endothelial cells (SECs). Another molecule that has been shown to induce similar types of… CONTINUE READING

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