Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice.

@article{Boer2013LipopolysaccharideIT,
  title={Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice.},
  author={J Daan de Boer and Joris J. T. H. Roelofs and Alex F. de Vos and Regina de Beer and Marcel Schouten and Tijmen J. Hommes and Arie Johan Hoogendijk and Onno J de Boer and Ingrid Stroo and Jaring S van der Zee and Cornelis van't Veer and Tom van der Poll},
  journal={American journal of respiratory cell and molecular biology},
  year={2013},
  volume={48 3},
  pages={382-9}
}
The complex biology of asthma compels the use of more relevant human allergens, such as house dust mite (HDM), to improve the translation of animal models into human asthma. LPS exposure is associated with aggravations of asthma, but the mechanisms remain unclear. Here, we studied the effects of increasing LPS doses on HDM-evoked allergic lung inflammation. To this end, mice were intranasally sensitized and challenged with HDM with or without increasing doses of LPS (0.001-10 μg). LPS dose… CONTINUE READING
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