Lipopolysaccharide induces calcitonin gene-related peptide in the RAW264.7 macrophage cell line.

@article{Ma2010LipopolysaccharideIC,
  title={Lipopolysaccharide induces calcitonin gene-related peptide in the RAW264.7 macrophage cell line.},
  author={Weiya Ma and Yvan Dumont and Freya G G Vercauteren and R{\'e}mi Quirion},
  journal={Immunology},
  year={2010},
  volume={130 3},
  pages={399-409}
}
SUMMARY Calcitonin gene-related peptide (CGRP) is widely distributed and plays important roles in a wide array of biological functions. It is enriched in primary sensory neurons and hence involved in nociception and neurogenic inflammation. Recent studies have shown that CGRP can be produced by immune cells such as monocytes/macrophages following inflammatory stimulation, suggesting a role in innate immunity. However, it is unclear how CGRP is up-regulated in macrophages and if it plays a role… CONTINUE READING

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