Lipopolysaccharide induces apoptotic insults to human alveolar epithelial A549 cells through reactive oxygen species-mediated activation of an intrinsic mitochondrion-dependent pathway

@article{Chuang2010LipopolysaccharideIA,
  title={Lipopolysaccharide induces apoptotic insults to human alveolar epithelial A549 cells through reactive oxygen species-mediated activation of an intrinsic mitochondrion-dependent pathway},
  author={Chi-Yuan Chuang and Tongxin Chen and Y G Cherng and Yu-Tyng Tai and Tianren Chen and Ruei-Ming Chen},
  journal={Archives of Toxicology},
  year={2010},
  volume={85},
  pages={209-218}
}
Alveolar type II epithelial cells can regulate immune responses to sepsis-induced acute lung injury. Lipopolysaccharide (LPS), an outer membrane component of Gram-negative bacteria, can cause septic shock. This study was designed to evaluate the cytotoxic effects of LPS on human alveolar epithelial A549 cells and its possible molecular mechanisms. Exposure of A549 cells to LPS decreased cell viability in concentration- and time-dependent manners. In parallel, LPS concentration- and time… CONTINUE READING
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