Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver.

Abstract

AIM To examine the activation of the Nalp3 inflammasome and its downstream targets following lipopolysaccharide (LPS)-induced stimulation in the liver. METHODS Six-to-eight-week-old C57BL/6 chow fed mice were injected intraperitoneally with 0.5 μg/g bodyweight LPS and sacrificed 2, 4, 6, 18 or 24 h later. LPS-induced liver damage was confirmed by a… (More)
DOI: 10.3748/wjg.v17.i43.4772

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Cite this paper

@article{Ganz2011LipopolysaccharideIA, title={Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver.}, author={Michal Ganz and T{\'i}mea Cs{\'a}k and Bharath D Nath and Gyongyi Szabo}, journal={World journal of gastroenterology}, year={2011}, volume={17 43}, pages={4772-8} }