Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells

@inproceedings{Echeverra2013LipopolysaccharideIA,
  title={Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells},
  author={C{\'e}sar Echeverr{\'i}a and Ignacio Montorfano and Daniela Sarmiento and Alvaro Becerra and Felipe N{\'u}{\~n}ez-Villena and Xavier F. Figueroa and Claudio Cabello-Verrugio and Alvaro A. Elorza and Claudia A Riedel and Felipe Simon},
  booktitle={Journal of cellular and molecular medicine},
  year={2013}
}
Endothelial dysfunction is crucial in endotoxaemia-derived sepsis syndrome pathogenesis. It is well accepted that lipopolysaccharide (LPS) induces endothelial dysfunction through immune system activation. However, LPS can also directly generate actions in endothelial cells (ECs) in the absence of participation by immune cells. Although interactions between LPS and ECs evoke endothelial death, a significant portion of ECs are resistant to LPS challenge. However, the mechanism that confers… CONTINUE READING
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