Lipopolysaccharide-induced tumor necrosis factor-alpha release is controlled by the central nervous system.

@article{Mastronardi2001LipopolysaccharideinducedTN,
  title={Lipopolysaccharide-induced tumor necrosis factor-alpha release is controlled by the central nervous system.},
  author={Claudio Alberto Mastronardi and Wen Hsin Yu and S M Mccann},
  journal={Neuroimmunomodulation},
  year={2001},
  volume={9 3},
  pages={148-56}
}
OBJECTIVE Lipopolysaccharide (LPS) injection in mammals orchestrates the release of many proinflammatory and anti-inflammatory cytokines. Intravenous administration of 0.2 mg/kg of LPS into unanesthetized rats with indwelling jugular catheters provoked a rapid, 50-fold increase in plasma tumor necrosis factor (TNF)-alpha within 30 min, which declined by 60% by 120 min. To test our hypothesis that such a rapid increase of TNF-alpha would be either neurally or hormonally controlled, the effect on… CONTINUE READING