Lipopolysaccharide-induced murine embryonic resorption involves nitric oxide-mediated inhibition of the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase.

@article{Aisemberg2012LipopolysaccharideinducedME,
  title={Lipopolysaccharide-induced murine embryonic resorption involves nitric oxide-mediated inhibition of the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase.},
  author={Julieta Aisemberg and Mar{\'i}a Victoria Bariani and Claudia A. Vercelli and Manuel Luis Wolfson and Ana Mar{\'i}a Franchi},
  journal={Reproduction},
  year={2012},
  volume={144 4},
  pages={447-54}
}
The initial inactivation of prostaglandins (PGs) is mediated by 15-hydroxyprostaglandin dehydrogenase (15-PGDH). PGs are potent mediators of several biological processes, including inflammation and reproduction. In uterus, PGs play a key role in infection-induced pregnancy loss, in which concentration of this mediator increased. This process is accompanied with the induction of nitric oxide synthase expression and a marked increase in uterine levels of nitric oxide. There is no information… CONTINUE READING

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