Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion.

@article{Harmey2002LipopolysaccharideinducedMG,
  title={Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion.},
  author={Judith H. Harmey and Corazon D. Bucana and Weixin Lu and Anne Marie Byrne and Susan Mcdonnell and Conor Lynch and David Bouchier-Hayes and Zhongyun Dong},
  journal={International journal of cancer},
  year={2002},
  volume={101 5},
  pages={415-22}
}
Endotoxin/lipopolysaccharide (LPS), a cell wall component of Gram-negative bacteria, is a potent inflammatory stimulus. We previously reported that LPS increased the growth of experimental metastases in a murine tumor model. Here, we examined the effect of LPS exposure on key determinants of metastasis-angiogenesis, tumor cell invasion, vascular permeability, nitric oxide synthase (NOS) and matrix metalloproteinase 2 (MMP2) expression. BALB/c mice bearing 4T1 lung metastases were given an… CONTINUE READING
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