Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-alpha.

  title={Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-alpha.},
  author={Johannes Barsig and Susanne K{\"u}sters and Katrin Vogt and H. D. Volk and Gisa Tiegs and Albrecht Wendel},
  journal={European journal of immunology},
  volume={25 10},
Interleukin (IL)-10 is known to protect mice against the lethal effects of lipopolysaccharides (LPS) and is considered to be an anti-inflammatory cytokine which suppresses the production of pro-inflammatory cytokines. We have examined the interactions of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) with IL-10. Neutralization of TNF-alpha in murine bone marrow-derived macrophages resulted in a significant reduction of LPS-inducible IL-10 production. In mice, injection of… CONTINUE READING


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