Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

@article{Fenn2012LipopolysaccharideinducedI,
  title={Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice},
  author={Ashley M. Fenn and Christopher J Henry and Y Huang and Allison M. Dugan and Jonathan P. Godbout},
  journal={Brain, Behavior, and Immunity},
  year={2012},
  volume={26},
  pages={766-777}
}
In several models of aging, microglia become more inflammatory and reactive to immune challenges. For example, peripheral LPS injection causes exaggerated microglial activation associated with prolonged sickness and depressive-like behavior in aged BALB/c mice. Therefore, the purpose of this study was to determine the extent to which age-related amplified microglial activation was associated with reduced sensitivity to the anti-inflammatory and M2 promoting cytokines interleukin (IL)-10 and IL… CONTINUE READING

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