Lipopolysaccharide-induced inflammation of bronchi and emphysematous changes of pulmonary parenchyma in miniature pigs (Sus scrofa domestica)

Abstract

Lipopolysaccharide (LPS) is widely used to induce chronic obstructive pulmonary disease (COPD) in animal models. Rodents are most commonly used to model COPD, but their substantial anatomic and physiological differences from humans present a challenge in the research of COPD pathogenesis. The authors induced COPD in miniature pigs by intratracheal… (More)
DOI: 10.1038/laban.160

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