Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

@article{OConnor2009LipopolysaccharideinducedDB,
  title={Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice},
  author={Jason C. O'Connor and Marcus A. Lawson and Caroline Andr{\'e} and M Moreau and Jacques Lestage and Nathalie Castanon and Keith W. Kelley and Robert Dantzer},
  journal={Molecular Psychiatry},
  year={2009},
  volume={14},
  pages={511-522}
}
Although elevated activity of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) has been proposed to mediate comorbid depression in inflammatory disorders, its causative role has never been tested. We report that peripheral administration of lipopolysaccharide (LPS) activates IDO and culminates in a distinct depressive-like behavioral syndrome, measured by increased duration of immobility in both the forced-swim and tail suspension tests. Blockade of IDO activation either… CONTINUE READING
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