Lipopolysaccharide-induced NF-kappaB activation in human endothelial cells involves degradation of IkappaBalpha but not IkappaBbeta.

Abstract

We studied the signal transduction pathways involved in NF-kappaB activation and the induction of the cytoprotective A20 gene by lipopolysaccharide (LPS) in human umbilical vein endothelial cells (HUVEC). LPS induced human A20 mRNA expression with a maximum level 2 h after stimulation. The proteasome inhibitor N-acetyl-leucinyl-leucinyl-norleucinal-H (ALLN… (More)

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@article{Zen1998LipopolysaccharideinducedNA, title={Lipopolysaccharide-induced NF-kappaB activation in human endothelial cells involves degradation of IkappaBalpha but not IkappaBbeta.}, author={Kouki Zen and Aly Karsan and Thomas Eunson and Elizabeth K Yee and John Marshall Harlan}, journal={Experimental cell research}, year={1998}, volume={243 2}, pages={425-33} }