Lipopolysaccharide increases resistin gene expression in vivo and in vitro

  title={Lipopolysaccharide increases resistin gene expression in vivo and in vitro},
  author={Shao-Chun Lu and W. Y. Shieh and Chia-Ying Chen and Shu-Ching Hsu and Hui-Ling Chen},
  journal={FEBS Letters},

New Role of Resistin in Lipopolysaccharide-Induced Liver Damage in Mice

The augmentation of LPS-induced liver damage caused by resistin seems to involve, at least in part, up-regulation of hepatic inflammation via mechanisms most likely involving the coagulation cascade and fibrin accumulation.

Resistin is more abundant in liver than adipose tissue and is not up-regulated by lipopolysaccharide.

Elevated serum resistin levels are not indicative for inflammation of AT or liver in a manner similar to known inflammatory markers such as IL-1beta, IL-6, or TNFalpha, which implies that resistin should not be considered only as an adipokine in humans.

Pituitary Resistin Gene Expression Is Upregulated in vitro and in vivo by Dexamethasone but Is Unaffected by Rosiglitazone

Pituitary resistin mRNA levels are robustly stimulated by corticosteroids, particularly at the time of puberty, consistent with the previous suggestion that resistin may be involved in maturation of the hypothalamic-pituitary axis.

Proinflammatory Properties Resistin, an Adipokine with Potent

The results indicate that resistin is a new and important member of the cytokine family with potent regulatory functions and makes it a novel and interesting therapeutic target in chronic inflammatory diseases such as rheumatoid arthritis.

Resistin: an adipocyte‐derived hormone. Has it a role in diabetes and obesity?

The purpose of this review is to summarize the experimental findings to date and to discuss the extent to which the original hypotheses relating to resistin have been confirmed or questioned.

Role of resistin in inflammation and inflammation-related diseases.

Recently, resistin was found to be relevant to inflammation and inflammation-related diseases like atherosclerosis and arthritis and was firstly proposed to be involved in insulin resistance and type 2 diabetes.

Resistin, an Adipokine with Potent Proinflammatory Properties1

The results indicate that resistin is a new and important member of the cytokine family with potent regulatory functions and makes it a novel and interesting therapeutic target in chronic inflammatory diseases such as rheumatoid arthritis.



Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.

It is concluded that the recently described relationships of murine resistin/Fizz3 expression with obesity, insulin resistance, and PPAR-gamma action may not readily translate to humans.

Decreased resistin expression in mice with different sensitivities to a high-fat diet.

It is shown that feeding a high-fat diet is not a primary determinant of resistin regulation, and obesity induced by gold thioglucose injection in FVB/n mice reduces the expression ofresistin in isolated adipocytes, arguing for decreased expression of resistsin as a hallmark of obesity.

Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists*

It is shown that resistin expression is significantly decreased in the white adipose tissue of several different models of obesity including the ob/ob, db/db, tub/tub, and KKAy mice compared with their lean counterparts, and decreases in Resistin expression are not required for the antidiabetic actions of peroxisome proliferator-activated receptor γ agonists.

Resistin gene expression in human adipocytes is not related to insulin resistance.

Together these findings do not support an important role of adipose-tissue resistin gene expression in human insulin resistance.

Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-α in adipose tissue

It is demonstrated that the expression of resistin and RELM α are similarly regulated in adipose tissue despite the fact that RELMα is exclusively expressed in the stromal vascular fraction of adipose tissues and not in adipocytes.

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.

Induction of leptin during the host response to infection may contribute to the anorexia of infection, as assessed by immuknoprecipitation and Western blotting.

Tumor Necrosis Factor α Is a Negative Regulator of Resistin Gene Expression and Secretion in 3T3-L1 Adipocytes

It is suggested that TNFα is a pivotal negative regulator of resistin gene expression, which may have important implications for the pathogenesis of insulin resistance and its link to obesity.

Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle.

  • I. NagaevU. Smith
  • Biology, Medicine
    Biochemical and biophysical research communications
  • 2001
Resistin gene expression with real-time RT-PCR in human isolated fat cells, adipose tissue, and muscle from 42 individuals of varying degrees of overweight and who had normal insulin sensitivity or were insulin-resistant or Type 2 diabetic samples showed no difference.

The hormone resistin links obesity to diabetes

It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.

Insulin resistance and substrate utilization in human endotoxemia.

LPS administration results in metabolic responses very similar to those observed in sepsis and could provide a useful model for the study of insulin resistance in human critical illness.