Lipopolysaccharide increased the expression levels of IL-18, ICE and IL-18 R in murine Leydig cells.

@article{Abuelhija2008LipopolysaccharideIT,
  title={Lipopolysaccharide increased the expression levels of IL-18, ICE and IL-18 R in murine Leydig cells.},
  author={Mahmoud Abuelhija and Eitan Lunenfeld and Talia Eldar-Geva and Mahmoud M Huleihel},
  journal={American journal of reproductive immunology},
  year={2008},
  volume={60 2},
  pages={151-9}
}
PROBLEM This study examined the effect of lipopolysaccharide (LPS) on the capacity of Leydig cells to produce and express interleukin-18 (IL-18), IL-18 receptor (IL-18R) and the IL-1beta-converting enzyme (ICE) (IL-18 family), under in vitro conditions. METHOD OF STUDY Primary Leydig cells (LCs) were isolated from murine testis by the Percoll technique, and cultured both in the presence and absence of LPS (0.1, 1, 5 microg/mL) for 3 and 24 hr. LCs were examined for their capacity to produce… CONTINUE READING
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Over-expression of IL-18 in testicular tissues of immature as compared to adult mice; constitutive production by Leydig and germ cells

  • M Huleihel, K Brawm, G Potashnik, E Lunenfeld
  • Hum Reprod
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