Lipopolysaccharide impairs long-term potentiation and recognition memory and increases p75NTR expression in the rat dentate gyrus.

@article{Hennigan2007LipopolysaccharideIL,
  title={Lipopolysaccharide impairs long-term potentiation and recognition memory and increases p75NTR expression in the rat dentate gyrus.},
  author={Amy Hennigan and Claire Trotter and A M Clare Kelly},
  journal={Brain research},
  year={2007},
  volume={1130 1},
  pages={158-66}
}
The role of the neurotrophins, including nerve growth factor, in synaptic plasticity is well established. These proteins exert their effects via activation of Trk receptor tyrosine kinases and the p75 neurotrophin receptor (p75NTR). While Trk receptor activation is associated with functions such as cell survival, learning and enhancement of synaptic transmission, p75NTR can modulate long-term depression and has been reported to be a regulator of apoptosis. Peripheral administration of… CONTINUE READING