Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

@inproceedings{Erickson2012LipopolysaccharideIA,
  title={Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier},
  author={Michelle A. Erickson and Pehr E. Hartvigson and Y. Morofuji and Joshua B. Owen and David Butterfield and W. A. Banks},
  booktitle={Journal of Neuroinflammation},
  year={2012}
}
Defects in the low density lipoprotein receptor-related protein-1 (LRP-1) and p-glycoprotein (Pgp) clearance of amyloid beta (Aβ) from brain are thought to contribute to Alzheimer’s disease (AD). We have recently shown that induction of systemic inflammation by lipopolysaccharide (LPS) results in impaired efflux of Aβ from the brain. The same treatment also… CONTINUE READING