Lipopolysaccharide from Gut Microbiota Modulates α-Synuclein Aggregation and Alters Its Biological Function.

@article{Bhattacharyya2019LipopolysaccharideFG,
  title={Lipopolysaccharide from Gut Microbiota Modulates $\alpha$-Synuclein Aggregation and Alters Its Biological Function.},
  author={Dipita Bhattacharyya and Ganesh M Mohite and Janarthanan Krishnamoorthy and Nilanjan Gayen and Surabhi Mehra and Ambuja Navalkar and Samuel A. Kotler and Bhisma N Ratha and Anirban Ghosh and Rakesh Kumar and Kanchan Garai and Atin Kumar Mandal and Samir K. Maji and Anirban Bhunia},
  journal={ACS chemical neuroscience},
  year={2019},
  volume={10 5},
  pages={
          2229-2236
        }
}
Altered intestinal permeability has been correlated with Parkinson's pathophysiology in the enteric nervous system, before manifestations in the central nervous system (CNS). The inflammatory endotoxin or lipopolysaccharide (LPS) released by gut bacteria is known to modulate α-synuclein amyloidogenesis through the formation of intermediate nucleating species. Here, biophysical techniques in conjunction with microscopic images revealed the molecular interaction between lipopolysaccharide and… 
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