Lipopolysaccharide-free heat shock protein 60 activates T cells.

@article{Osterloh2004LipopolysaccharidefreeHS,
  title={Lipopolysaccharide-free heat shock protein 60 activates T cells.},
  author={Anke Osterloh and Franziska Meier-Stiegen and Alexandra Veit and Bernhard Fleischer and Arne von Bonin and Minka Breloer},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 46},
  pages={47906-11}
}
A possible function of eukaryotic heat shock protein 60 (Hsp60) as endogenous danger signal has been controversially discussed in the past. Hsp60 was shown to induce the secretion of proinflammatory cytokines in professional antigen-presenting cells and to enhance the activation of T cells in primary stimulation. However, in vitro activation of macrophages by Hsp60 was attributed to contaminating endotoxin in the recombinant Hsp60 protein preparations. Here, we employ low endotoxin recombinant… CONTINUE READING

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