Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor.

@article{Dogan2004LipopolysaccharideFI,
  title={Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor.},
  author={Muberra Devrim Dogan and Shreya A Patel and Alla Y Rudaya and Alexandre A Steiner and M Sasvari- Szekely and Andrej A. Romanovsky},
  journal={British journal of pharmacology},
  year={2004},
  volume={143 8},
  pages={1023-32}
}
As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity. However, our recent studies suggest that CAP blocks the first phase via a non-neural… CONTINUE READING
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