Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria

Abstract

T cell–independent type 1 agonists such as Gram-negative bacterial lipopolysaccharides can stimulate B lymphocytes to proliferate and produce antibodies by signaling through Toll-like receptors. This phenomenon is well established in vitro, yet polyclonal B cell responses after bacterial infection in vivo are often weak and short-lived. We show here that B… (More)
DOI: 10.1038/ni1246

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Cite this paper

@article{Lu2005LipopolysaccharideDB, title={Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria}, author={Mingfang Lu and Mei Zhang and Akira Takashima and Jerrold P Weiss and Michael A. Apicella and Xiang-hong Li and Dorothy Yuan and Robert S. Munford}, journal={Nature Immunology}, year={2005}, volume={6}, pages={989-994} }