Lipopolysaccharide challenge of humans as a model for chronic obstructive lung disease exacerbations.

@article{Kharitonov2007LipopolysaccharideCO,
  title={Lipopolysaccharide challenge of humans as a model for chronic obstructive lung disease exacerbations.},
  author={Sergei A. Kharitonov and Ulf Sj{\"o}bring},
  journal={Contributions to microbiology},
  year={2007},
  volume={14},
  pages={83-100}
}
Endotoxin, or lipopolysaccharide (LPS), is a constituent of the outer cell membrane of Gram-negative bacteria. LPS is a highly potent proinflammatory substance, that, when inhaled, dose-dependently causes fever, chills, and bronchoconstriction. These symptoms are accompanied by a proinflammatory response in sputum and bronchoalveolar lavage fluid with elevation of neutrophils, macrophages and certain cytokines/chemokines. This response can be partially modified with certain drugs. Similar… CONTINUE READING

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