Lipopolysaccharide binding protein expression in primary human hepatocytes and HepG2 hepatoma cells.

@article{Grube1994LipopolysaccharideBP,
  title={Lipopolysaccharide binding protein expression in primary human hepatocytes and HepG2 hepatoma cells.},
  author={Baiba J Grube and C G Cochane and Richard D Ye and Chad E. Green and M E McPhail and Richard J Ulevitch and Peter S. Tobias},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 11},
  pages={8477-82}
}
Lipopolysaccharide (LPS)-binding protein (LBP) is a normal plasma protein and an acute phase reactant important for host responses to Gram-negative bacteria and LPS. LBP forms high affinity complexes with LPS which bind to CD14, a monocyte surface protein, to initiate the release of inflammatory mediators. We found that human primary hepatocytes synthesize LBP and that the synthesis is up-regulated by interleukin (IL)-6. To examine this phenomenon in more detail, we evaluated the capacity of IL… CONTINUE READING

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