Lipopolysaccharide and Interleukin-1 Depress Food-Motivated Behavior in Mice by a Vagal-Mediated Mechanism

@article{Bretdibat1995LipopolysaccharideAI,
  title={Lipopolysaccharide and Interleukin-1 Depress Food-Motivated Behavior in Mice by a Vagal-Mediated Mechanism},
  author={J. L. Bretdibat and R-M. Bluth{\'e} and Susan Kent and Keith W. Kelley and Robert Dantzer},
  journal={Brain, Behavior, and Immunity},
  year={1995},
  volume={9},
  pages={242-246}
}
In order to assess the role of vagal nerve afferents in the decrease in food-motivated behavior induced by proinflammatory cytokines, the effects of lipopolysaccharide (LPS, 400 micrograms/kg ip) and recombinant human interleukin-1 beta (IL-1, 750-1500 ng/mouse ip) were tested on nose poke for food in vagotomized and sham-operated mice. Subdiaphragmatic vagotomy attenuated the decrease in response rate induced by IL-1 and LPS. These results suggest that the peripheral immune message is… CONTINUE READING

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