Lipopolysaccharide administration enhances hypoxic-ischemic brain damage in newborn rats.

Abstract

AIM To determine whether inflammation and hypoxic-ischemic insult (HI) act additively to cause brain damage in perinatal animals by examining the dose-response effect of lipopolysaccharide (LPS) administration on HI insult in neonatal rat pups. METHODS Seven-day-old Wistar rats (n = 119) were divided into three groups: (i) a group that received a pre… (More)

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@article{Yang2004LipopolysaccharideAE, title={Lipopolysaccharide administration enhances hypoxic-ischemic brain damage in newborn rats.}, author={Li Yang and Hiroshi Sameshima and Tomoaki Ikeda and Tsuyomu Ikenoue}, journal={The journal of obstetrics and gynaecology research}, year={2004}, volume={30 2}, pages={142-7} }