Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes.

@article{GuijarroMuoz2014LipopolysaccharideAT,
  title={Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes.},
  author={Irene Guijarro-Mu{\~n}oz and Marta Compte and Ana {\'A}lvarez-Cienfuegos and Luis Alvarez-Vallina and Laura Sanz},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 4},
  pages={2457-68}
}
Pericytes and mesenchymal stem cells (MSCs) are ontogenically related, and in fact, no significant phenotypic differences could be observed by flow cytometry. Transcriptome analysis of human pericytes and MSCs revealed that 43 genes were up-regulated more than 10-fold in pericytes compared with MSCs. Identification of Toll-like receptor 4 (TLR4) as one of the most abundant RNA species in pericytes with respect to MSCs and confirmation of TLR4 expression on the cell surface led us to obtain a… CONTINUE READING

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