Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin.

@article{Monick2001LipopolysaccharideAA,
  title={Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin.},
  author={Martha M. Monick and Aaron Brent Carter and Pamela K. Robeff and Dawn M. Flaherty and Michael W. Peterson and Gary W. Hunninghake},
  journal={Journal of immunology},
  year={2001},
  volume={166 7},
  pages={4713-20}
}
Exposure of human alveolar macrophages to bacterial LPS results in activation of a number of signal transduction pathways. An early event after the alveolar macrophage comes in contact with LPS is activation of the phosphatidylinositol 3 kinase (PI 3-kinase). This study evaluates the downstream effects of that activation. We observed that LPS exposure results in phosphorylation of Akt (serine 473). We found this using both phosphorylation-specific Abs and also by in vivo phosphorylation with… CONTINUE READING
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