Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development

@article{Pang2010LipopolysaccharideactivatedMI,
  title={Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development},
  author={Yi Pang and Lucinda Campbell and Bangxu Zheng and L Fan and Philip Rhodes},
  journal={Neuroscience},
  year={2010},
  volume={166},
  pages={464-475}
}
Damage to oligodendrocyte (OL) progenitor cells (OPCs) and hypomyelination are two hallmark features of periventricular leukomalacia (PVL), the most common form of brain damage in premature infants. Clinical and animal studies have linked the incidence of PVL to maternal infection/inflammation, and activated microglia have been proposed to play a central role. However, the precise mechanism of how activated microglia adversely affects the survival and development of OPCs is still not clear… CONTINUE READING

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Effects of lipopolysaccharide on oligodendrocyte progenitor cells are mediated by astrocytes and microglia

  • Y ang, Z Cai, PG Rhodes
  • J Neurosci Res
  • 2000
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