Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2

  title={Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2},
  author={Sachiko Akashi and Shin-ichiroh Saitoh and Yasutaka Wakabayashi and Takane Kikuchi and Noriaki Takamura and Yoshinori Nagai and Yutaka Kusumoto and Koichi Fukase and Shoichi Kusumoto and Yoshiyuki Adachi and Atsushi Kosugi and Kensuke Miyake},
  journal={The Journal of Experimental Medicine},
  pages={1035 - 1042}
Toll-like receptors (TLRs) are innate recognition molecules for microbial products, but their direct interactions with corresponding ligands remain unclarified. LPS, a membrane constituent of gram-negative bacteria, is the best-studied TLR ligand and is recognized by TLR4 and MD-2, a molecule associated with the extracellular domain of TLR4. Although TLR4-MD-2 recognizes LPS, little is known about the physical interaction between LPS and TLR4-MD-2. Here, we demonstrate cell surface LPS-TLR4-MD… CONTINUE READING


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popolysaccharide rapidly traffics to and from the Golgi apparatus with the toll - like receptor 4 - MD2 - CD 14 complex in a process that is distinct from the initiation of signal transduction

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