Lipopolysaccharide-Induced Neuronal Activation in the Paraventricular and Dorsomedial Hypothalamus Depends on Ambient Temperature

@inproceedings{Wanner2013LipopolysaccharideInducedNA,
  title={Lipopolysaccharide-Induced Neuronal Activation in the Paraventricular and Dorsomedial Hypothalamus Depends on Ambient Temperature},
  author={Samuel Penna Wanner and Kyoko Yoshida and Vladimir A. Kulchitsky and Andrei I. Ivanov and Kazuyuki Kanosue and Andrej A. Romanovsky},
  booktitle={PloS one},
  year={2013}
}
Systemic inflammatory response syndrome is associated with either fever or hypothermia, but the mechanisms responsible for switching from one to the other are unknown. In experimental animals, systemic inflammation is often induced by bacterial lipopolysaccharide (LPS). To identify the diencephalic and brainstem structures involved in the fever-hypothermia switch, we studied the expression of c-Fos protein, a marker of neuronal activation, in rats treated with the same high dose of LPS (0.5 mg… CONTINUE READING

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