Lipopolysaccharide-Binding Protein Plasma Levels and Liver TNF-Alpha Gene Expression in Obese Patients: Evidence for the Potential Role of Endotoxin in the Pathogenesis of Non-Alcoholic Steatohepatitis

@article{GuerraRuiz2007LipopolysaccharideBindingPP,
  title={Lipopolysaccharide-Binding Protein Plasma Levels and Liver TNF-Alpha Gene Expression in Obese Patients: Evidence for the Potential Role of Endotoxin in the Pathogenesis of Non-Alcoholic Steatohepatitis},
  author={Armando Ra{\'u}l Guerra Ruiz and Fernando Casafont and Javier Crespo and Amal{\'i}a Cay{\'o}n and Marta Mar{\'i}a Mayorga and {\'A}ngel Est{\'e}banez and Jos{\'e} Carlos Fernadez-Escalante and Fernando Pons-Romero},
  journal={Obesity Surgery},
  year={2007},
  volume={17},
  pages={1374-1380}
}
BackgroundSome lines of evidence suggest that endotoxin may induce non-alcoholic steatohepatitis (NASH) in a background of fatty liver. However, a clear association between increased endotoxemia and development of steatohepatitis in obese patients has not been confirmed. We aim to assess the endotoxemic state of patients with non-alcoholic fatty liver disease (NAFLD) and its relationship with the liver expression of TNF-α and the presence of NASH.MethodsProspective study comprising 40 patients… Expand
Endotoxinemia contributes to steatosis, insulin resistance and atherosclerosis in chronic hepatitis C: the role of pro-inflammatory cytokines and oxidative stress
TLDR
Endotoxinemia occurs with high frequency in chronic hepatitis C patients and contributes to the development of hepatic steatosis, IR and atherosclerosis through increased pro-inflammatory cytokines and oxidative stress. Expand
Pro-Inflammatory Cytokines but Not Endotoxin-Related Parameters Associate with Disease Severity in Patients with NAFLD
TLDR
Elevated levels of LPS, LBP, sCD14, iFABP and TLR2,4 in obese patients compared to healthy controls, however, these parameters remained unaltered within patients with limited liver disease (NAFL) compared to NASH/NASH with fibrosis subgroups, highlighting the need for additional larger studies in unravelling further mechanistic insights. Expand
Role of tumor necrosis factor α (TNFα) in the onset of fructose-induced nonalcoholic fatty liver disease in mice.
TLDR
The data suggest that TNFα plays a casual role in the onset of fructose-induced liver damage as well as insulin resistance in mice through signaling cascades downstream of TNFR1. Expand
Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model
TLDR
Reduction of LPS and restoration of intestinal TJP may be a novel therapeutic strategy for treatment of liver fibrosis development in NASH via the inhibition of HSC activation. Expand
Association of lipopolysaccharide-binding protein with increases in liver fat in African ancestry men
TLDR
It is determined that among African ancestry individuals, LBP levels are completely environmentally determined and that levels may be associated with increases in liver fat accumulation, suggesting that LBP might be entirely environmentally determined in this population. Expand
Association between endotoxemia and histological features of nonalcoholic fatty liver disease
TLDR
LBP/EndoCab IgG were not correlated with lobular inflammation or fibrosis and more accurate LPS biomarkers are required to stringently assess the contribution of endotoxemia to conventional NASH. Expand
Small Intestinal Bacterial Overgrowth in Nonalcoholic Steatohepatitis: Association with Toll-Like Receptor 4 Expression and Plasma Levels of Interleukin 8
TLDR
NASH patients have a higher prevalence of small intestinal bacterial overgrowth which is associated with enhanced expression of TLR-4 and release of IL-8, and SIBO may have an important role in NASH through interactions with TLR -4 and induction of the pro-inflammatory cytokine, IL- 8. Expand
PERIPHERAL BLOOD ENDOTOXIN LEVELS ARE NOT ASSOCIATED WITH SMALL INTESTINAL BACTERIAL OVERGROWTH IN NONALCOHOLIC FATTY LIVER DISEASE WITHOUT CIRRHOSIS.
TLDR
Serum endotoxin levels did not differ between patients with and without SIBO, nor did these levels change after antibacterial therapy, virtually ruling out the possibility that elevated endotoxinemia in non-cirrhotic patients with NAFLD is associated with SIBO. Expand
Female Mice Are More Susceptible to Nonalcoholic Fatty Liver Disease: Sex-Specific Regulation of the Hepatic AMP-Activated Protein Kinase-Plasminogen Activator Inhibitor 1 Cascade, but Not the Hepatic Endotoxin Response
TLDR
The data suggest that the sex-specific Differences in the susceptibility to NAFLD are associated with differences in the regulation of the adiponectin-AMPK-PAI-1 signaling cascade. Expand
Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice
TLDR
The results indicate that deficiency of TNFR1 signaling in hepatocytes does not protect from diet-induced NASH, however, improved insulin resistance in this model strengthens the role of the liver in glucose homeostasis. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis
TLDR
Patients with non-alcoholic steatohepatitis have a higher prevalence of small intestinal bacterial overgrowth, as assessed by the14C-d-xylose-lactulose breath test, and higher TNF-α levels in comparison with control subjects, but this is not accompanied by increased intestinal permeability or elevated endotoxin levels. Expand
Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis.
TLDR
It is suggested that in metabolic syndrome, patients may likewise have a greater intestinal mucosa permeability and increased lipopolysaccharide levels in portal blood that can contribute to the liver inflammatory damage. Expand
Gene expression of tumor necrosis factor α and TNF‐receptors, p55 and p75, in nonalcoholic steatohepatitis patients
TLDR
Findings suggest that the TNF‐α system may be involved in the pathogenesis of NASH and the levels of mRNA‐p55 are increased in the liver tissue of NASh patients. Expand
Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis.
TLDR
It is demonstrated that hepatic macrophage dysfunction occurs in obesity and suggested that this might promote steatohepatitis by sensitizing hepatocytes to endotoxin. Expand
Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement
TLDR
The subset of ascitic cirrhotic patients with marked immune and hemodynamic derangement is identified by increased LBP levels, which suggests the involvement of enteric bacteria or their products in the triggering of the process. Expand
Serum levels of tumor necrosis factor-alpha are increased in obese patients with noninsulin-dependent diabetes mellitus.
TLDR
Serum levels of TNF-alpha were significantly reduced in the obese patients with noninsulin-dependent diabetes mellitus after the treatment (P < 0.01), while those in the nonobese NIDDM patients were unchanged. Expand
Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity.
Fat tissue is a significant source of endogenous tumor necrosis factor alpha (TNFalpha), the pluripotent cytokine that plays an important role as a mediator of the peripheral insulin resistance foundExpand
Non-alcoholic fatty liver disease: a multicentre clinical study by the Italian Association for the Study of the Liver.
TLDR
The typical Italian patient with non-alcoholic fatty liver disease is a young male, obese, not diabetic, with a variable incidence of dyslipidaemia and hyperinsulinaemia, and at multivariate analysis no single factor was found to be an independent predictor of hepatic lesions. Expand
Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response.
TLDR
The results show that L BP mRNA is induced during hepatic inflammation and suggest that LBP is an acute-phase protein important in regulating the in vivo response to endotoxin. Expand
Cytokines and NASH: A pilot study of the effects of lifestyle modification and vitamin E
TLDR
Patients with NASH have dysregulated cytokine metabolism similar to, but less pronounced than abnormalities documented in AH, whereas the level of vitamin E supplementation used in this short‐term pilot study provided no apparent added benefit. Expand
...
1
2
3
4
5
...