Lipopolysaccharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NFkappaB and MAPKs signaling pathways.

@article{Yang2007LipopolysaccharideR,
  title={Lipopolysaccharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NFkappaB and MAPKs signaling pathways.},
  author={Yixin Yang and Houde Zhou and Yunbo Yang and Weisong Li and Min Zhou and Zhaoyang Zeng and Wei Xiong and Minghua Wu and He Huang and Yanghong Zhou and Cong Peng and Chen Huang and Xiaolin Li and Guiyuan Li},
  journal={Molecular immunology},
  year={2007},
  volume={44 5},
  pages={984-92}
}
The lipopolysaccharide (LPS) of Gram-negative bacteria induces the expression of cytokines and proinflammatory genes via the TLR4 signaling pathway in diverse cell types. The purpose of the present study was to test the hypothesis that the nasopharynx epithelial cells (NECs) could recognize and respond to LPS. The underlying molecular mechanisms were further elucidated in the NEC line 5-8F for its ability to activate the NFkappaB and TNF-alpha reporter genes, in response to LPS. After LPS… CONTINUE READING

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